Prof. Dr. Yanjie Chao
Warm greetings!
I am principal investigator and professor at the Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences (formerly known as the Institut Pasteur of Shanghai, CAS), as well as a professor at the University of Chinese Academy of Sciences (UCAS), on the east coast of China. As a molecular biologist and microbiologist, I obtained my PhD training at the Max-Planck Institute for Infection Biology and Humboldt University in Berlin, Germany. I completed postdoc trainings with Prof. Jörg Vogel at the University of Würzburg in Germany, and with Prof. Andrew Camilli at the Howard Hughes Medical Institute and Tufts University School of Medicine in the United States of America.
My research interest is to understand how pathogenic and commensal bacteria control their gene expression to colonize the host and cause disease, especially the gene regulations at the post-transcriptional level mediated by RNA-binding proteins and small noncoding RNAs (sRNAs). Using high-throughput sequencing and systems-biology approaches, I have identified a novel class of sRNAs that are derived from the 3′-UTR of bacterial mRNAs (see Chao et al, 2012, 2016, 2017; Wang et al, 2020). My lab continues to investigate the general mechanisms dictating the fate of cellular RNAs from transcription to translation, to regulation and degradation. We are currently investigating the RNA-RNA interactome at the systems-level in live bacterial cells using the newly established iRIL-seq approach (Liu et al, 2023 Nature Communications; Wu et al, 2024 in preparation).
Current lab members:
2 Postdocs: Dr. Fang Liu, Dr. Rui Dong
6 PhD students: Philippe Icyishaka, Xingyu Lin, Haoyu Wang, Shuo Zhang, Maolin Wang, Ziying Chen
3 Master students: Sihui Jin, Yujie Lu, Hongnian Jiang
3 Chao-Falush Joint Members: Dr. Sarah Svensson, Zhizhou Jia, Han Zhang
Past lab members: Zhiyuan Liu (2022-2023), Kejing Wu (2020-2024)
We are searching for talented postdocs and students all over the world, please contact me if you are interested in working with us on RNA research in Shanghai! Fellowship is available from the Chinese Academy of Sciences (CAS).
Yanjie Chao, PhD
Twitter: @yanjiechao
We are pleased to organize the first Symposium on Microbial RNA and Transcription in Shanghai, China! We invite everyone in the aera to participate in this special event in 2024!
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Keywords: small RNA, sRNA, Hfq, CRISPR, 3’UTR, RNA sequencing, Salmonella, Bacterial pathogens, transcriptomics, genomics, pathogenesis, SPI-1, HilD, DapZ, PhoP, PinT, CpxR, CpxP, CpxQ, 非编码小RNA，RNA结合蛋白，链特异性RNA测序，高通量测序，沙门伤寒氏杆菌，病原微生物，转录组学，细菌毒力因子，双组分系统，华中农业大学校友
Yanjie Chao 